Elevation of interleukin 8 in cerebrospinal fluid in neuropsychiatric systemic lupus erythematosus
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چکیده
Objective: We investigated the levels of cerebrospinal fluid (CSF) interleukin 8 (IL-8) in neuropsychiatric manifestations in systemic lupus erythematosus (NP-SLE). Methods: CSF samples were obtained from 48 SLE patients (35 patients with diffuse psychiatric/ neuropsychological syndromes [diffuse NP-SLE] and 13 patients with neurologic syndromes or peripheral neuropathy [focal NP-SLE]) as well as from 20 patients with noninflammatory neurological diseases. CSF IL-6 and IL-8 levels were determined using MH60.BSF2 cells or by ELISA (enzymelinked immunosorbent assay). Results: CSF IL-8 levels were significantly elevated in focal NP-SLE as well as in diffuse NP-SLE compared with control patients. There were no significant differences in CSF IL-8 levels between diffuse and focal NP-SLE. CSF IL-8 levels were significantly higher in patients diagnosed with acute confusional state than in those with other diffuse NP-SLE. CSF IL-8 levels were significantly correlated with CSF IL-6 levels in NP-SLE. Conclusions: These results indicate that CSF IL-8 is involved in the development of NP-SLE. These data also suggest that the common mechanism might be involved in the elevation of IL-6 and IL-8 in CSF in NP-SLE.
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تاریخ انتشار 2011